A botanical and nutrient blend developed to support healthy oestrogen metabolism by encouraging the production of the enzymes involved in the oestrogen detoxification process, and by supporting a healthy oestrobolome. Many of the enzymes required for biotransformation are also used in the clearance of xenoestrogens and other toxins. This formula includes TrueBroc® broccoli seed extract with myrosinase to increase the active metabolites of glucosinolates, such as DIM and sulforaphane. It also contains rosemary, as well as nutrients to support methylation and the enzymes induced by glucosinolates. Hormonal imbalances can heavily impact metabolism, mood, reproduction, stress regulation and weight management in men and women. Poor biotransformation of oestrogen has been linked with diseases such as hormone dependant cancers, endometriosis, PCOS, and infertility issues to name a few (1–3).
Oestrogen is the name for the collective group of metabolites which play a major function in women’s reproductive function, and a minor one in males. There are three major forms of oestrogen – oestrone (E1 or acyclic oestrogen), oestradiol (E2) which is the most active oestrogen and oestriol (E3) which is a weaker form on route to excretion. Oestrogen production is dependent on a complex negative feedback system in menstruating females. In men and postmenopausal women, it is mainly produced from the aromatisation of androgens. Oestrogen is metabolised through the liver before excretion. There are three different stages to liver detoxification of oestrogen, and every stage can vary slightly, resulting in a myriad of different metabolites that can have slightly differing effects on the body. The totality of all the metabolites of oestrogen contribute to the overall oestrogenic load. Dependent on enzymatic production, which can be affected by genes and environmental factors, one could end up with a varying amount of toxic oestrogen metabolites, which may increase the risk of DNA damage and the risks that brings (4).
Take 1 capsule daily.
Do not exceed the recommended dose, unless advised by your healthcare professional.
|Serving Size: 1 Capsule|
| ||Amount Per Serving|
|Riboflavin 5 Phosphate (1078% RI*)||15.1 mg|
|Selenomethione providing Selenium 50ug (91% RI*)||10 mg|
|TrueBroc (Broccoli seed extract) ||75 mg|
|Rosemary Extract (4.5% Carnosic Acid)||25 mg|
|Trimethylglycine (TMG)||25.3 mg|
|Choline Citrate||25 mg|
|Organic Spirulina||20 mg|
|Mustard Myrosinase ||7.5 mg|
|** Daily Value not established.|
Capsule Shell (Hydroxypropyl Methylcellulose)